Bowen has been nursing a minor injury since midway through the last international break, while Coufal and Kudus were struck by illness. Alvarez was rested having been in action for Mexico deep into the break.
David Moyes was yet to assess his players when speaking to the media on Friday afternoon after returning from Serbia.
“We’re only just back and we’ll find out a bit later,” the Scot said. “We left several behind, a couple had bits of viruses and flu like symptoms.
“I’ll pick up with the medical team and see what they feel and will have a bit of a better idea this afternoon."
Regular starters Alphonse Areola and Emerson were among those to start on the bench in Serbia and also come back into the side, though Kurt Zouma is missing due to a family matter so Nayef Aguerd is partnered by Konstantinos Mavropanos at the back.
West Ham XI: Areola, Coufal, Mavropanos, Aguerd, Emerson Palmieri, Alvarez, Ward-Prowse, Kudus, Soucek, Lucas Paqueta, Bowen
Subs: Fabianski, Cresswell, Fornals, Cornet, Ings, Ogbonna, Benrahma, Kehrer, Mubama
Time and date: 2pm GMT on Sunday December 3, 2023
Venue: London Stadium
TV and live stream: Sky Sports