Man United, along with neighbours City, are the top scorers in the Premier League with 11 goals from four games, while the Hammers have managed only one fewer.
The blow for West Ham is that they will be without their top scorer Michail Antonio, who was sent off in the closing stages of the 0-0 draw with Southampton for a rash challenge on Moussa Djenepo.
United will arrive at the London Stadium on the back of their shock 2-1 defeat by Young Boys but it is only a few days ago that they were basking in Cristiano Ronaldo’s second debut for the club after he scored twice in a 4-1 win over Newcastle.
And unlike that game, which was a victim of the 3pm Saturday blackout, the clash with West Ham will be one fans can catch live without being at the ground.
Where to watch West Ham vs Manchester United
TV channel: The match will be televised on Sky Sports Premier League and Main Event today, with coverage starting at 2pm.
Live stream: Sky Sports subscribers will be able to watch the match online via the website or Sky Go.