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* Apple, Microsoft biggest drag on S&P 500 and Nasdaq
* Spirit Airlines surges after JetBlue launches hostile takeover
* Indexes down: Dow 0.72%, S&P 0.92%, Nasdaq 1.26% (Updates to open)
By Amruta Khandekar
May 16 (Reuters) - Wall Street's main indexes fell on Monday as downbeat data out of China added to worries about a global economic slowdown against the backdrop of aggressive policy tightening by the U.S. Federal Reserve.
Chinese and European stock markets fell, while oil slid as data showed China's economic activity cooled sharply in April as COVID-19 lockdowns took a heavy toll on consumption, industrial production and employment.
Nine of the 11 major S&P sectors declined in morning trade. Technology and consumer discretionary stocks fell 1.6% and 1.8%, respectively.
Big growth companies such as Amazon.com, Alphabet Inc, Microsoft Corp, Apple Inc, Tesla Inc and Nvidia Corp slipped between 1.1% and 2.6%.
Energy shares outperformed and were up 1.5%.
Wall Street closed sharply higher on Friday, but still the S&P 500 and the Nasdaq indexes posted their longest weekly losing streaks in over a decade.
"Investors are just a little bit skeptical. They're just sort of testing the waters to see if the rally is going to continue or go back down," said Robert Pavlik, senior portfolio manager at Dakota Wealth Management.
"We're clearly not out of the woods as far as the economy is concerned. We haven't seen inflation peak yet, we can retest those lows and possibly move even lower."
Investors have been worried that aggressive interest rate hikes by the Fed to combat decades-high inflation could tip the U.S. economy into recession, with the conflict in Ukraine, supply chain snarls and the latest pandemic-related lockdowns in China exacerbating the situation.
Data on Monday showed factory activity in New York state slumped in May for the third time this year amid a collapse in new orders and shipments.
The S&P 500 and the tech-heavy Nasdaq have fallen 16.2% and 25.8%, respectively, so far this year, with growth stocks taking a hit on concerns that bigger interest rate hikes could hurt their future cash flows.
Traders are now pricing a near 86% chance of a 50 basis point hike by the Fed in June.
At 9:49 a.m. ET, the Dow Jones Industrial Average was down 231.10 points, or 0.72%, at 31,965.56, the S&P 500 was down 37.13 points, or 0.92%, at 3,986.76, and the Nasdaq Composite was down 148.58 points, or 1.26%, at 11,656.42.
Focus is now on the retail sales report due on Tuesday, after worrying inflation and consumer sentiment data last week.
Retailers such as Walmart Inc, Home Depot and Target Corp are due to report their quarterly results this week.
Spirit Airlines jumped 8.2% after JetBlue Airways launched a hostile all-cash takeover bid for the discount carrier. JetBlue shares slipped 3.4%. Shares of rival bidder Frontier Group Holdings gained 3.9%.
Netflix Inc rose 1.4% after Wedbush upgraded the streaming pioneer's stock to "outperform" from "neutral".
Declining issues outnumbered advancers for a 1.56-to-1 ratio on the NYSE and a 1.42-to-1 ratio on the Nasdaq.
The S&P index recorded one new 52-week high and 29 new lows, while the Nasdaq recorded 10 new highs and 60 new lows. (Reporting by Amruta Khandekar and Devik Jain in Bengaluru; Editing by Sriraj Kalluvila and Shounak Dasgupta)