Daniel Jones has failed to get New York's offense going through three games. New tight end Darren Waller has only been targeted 20 times and has 12 catches for 132 yards as the team's leading receiver. The Giants will be without Saquon Barkley, who they lost for about three weeks in Week 2 with an ankle injury in their lone win against the Arizona Cardinals.
Despite the Seahawks suffering early injuries, quarterback Geno Smith has hobbled through the season with running back Kenneth Walker III as each have scored four touchdowns. On the defense, Bobby Wagner is fourth in the league with 33 tackles.
Seattle has already won a tough road matchup, beating the Lions at Ford Field to rain on their parade after Detroit beat the defending champion Kansas City Chiefs.
Will the Giants be able to hold ground on their home turf? Or will the Seahawks repeat their road rage?
Giants vs. Seahawks odds, moneyline, over/under
Spread: Seahawks (-1.5)
Moneyline: Seahawks (-125); Giants (+105)
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NFL Week 4 odds, predictions and picks
Packers vs. Lions | Jaguars vs. Falcons | Bills vs. Dolphins | Panthers vs. Vikings | Bears vs. Broncos | Browns vs. Ravens | Texans vs. Steelers | Colts vs. Rams | Saints vs. Buccaneers | Eagles vs. Commanders | Titans vs. Bengals | Chargers vs. Raiders | Cowboys vs. Patriots | 49ers vs. Cardinals | Jets vs. Chiefs | Giants vs. Seahawks
Lorenzo Reyes: Seahawks 29, Giants 21
The Giants are just 1-11 in primetime games that Daniel Jones starts. They are historically inept on offense at home. Saquon Barkley may still be limited. I love Seattle on the moneyline here.
Tyler Dragon: Seahawks 24, Giants 17
The Seahawks scored 37 points in each of their two wins. The Giants have the second worst scoring offense in the league. Kenneth Walker, DK Metcalf and Tyler Lockett are going to cause problems for the Giants defense. Seattle wins its third straight game after a Week 1 hiccup.
Victoria Hernandez: Seahawks 25, Giants 20
The Seahawks simply have more momentum. They are battle tested on the road and are more balanced with playmakers on both offense and defense. The Giants will have had a few more days of rest after playing on Thursday night, but it's going to take more than that to come back from their Week 3 thrashing.
Jordan Mendoza: Seahawks 27, Giants 22
Seattle’s offense is on fire, and it gets a juicy matchup against a New York defense that hasn’t been able to stop much through three weeks. The Giants look more put together in another primetime game, but they aren’t able to stop Geno Smith and company.
You can view the full list of USA TODAY's NFL expert predictions here.
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This article originally appeared on USA TODAY: Seattle Seahawks at New York Giants: Game predictions, picks, odds