Seattle Seahawks at New Orleans Saints: Predictions, picks and odds for NFL Week 5 matchup

Returning from a trip to London, coach Dennis Allen's New Orleans Saints return home to play host to Pete Carroll and the Seattle Seahawks.

The Saints (1-3) look for their second win of the season and could be forced to play backup quarterback Andy Dalton in Week 5 due to an injury to starter Jameis Winston. Can Seahawks QB Geno Smith and Seattle take advantage en route to a road victory? Sunday's game is scheduled to kick off at 1 p.m. ET from Caesars Superdome.

Here's a look at the betting details and USA TODAY's NFL staff picks for the Seahawks vs. Saints Week 5 game:

Seahawks at Saints odds, moneyline and over/under

COMING BACK: Alvin Kamara eager to get back on the field, says he's 'ready to roll' vs. Seahawks

THE FUTURE?: Geno Smith is off to strong start in first season as Seahawks starter

NEW BUCKETS: The NFL has returned alternate helmets in 2022: Ranking all 13 from best to worst

NFL Week 5 predictions, picks and odds

Colts vs. Broncos | Giants vs. Packers | Falcons vs. Buccaneers | Bears vs. Vikings | Steelers vs. Bills | Lions vs. Patriots | Chargers vs. Browns | Seahawks vs. Saints | Texans vs. Jaguars | Titans vs. Commanders | Dolphins vs. Jets | 49ers vs. Panthers | Eagles vs. Cardinals

Lorenzo Reyes: Saints 27, Seahawks 23

The uncertainty at quarterback makes this a complicated play. And while Geno Smith has been a revelation for Seattle, I still think New Orleans has a better roster. Its issue is avoiding unforced errors. I think the safe play here is the Saints winning, with the Seahawks covering a spread that is pretty generous in the first place.

Week 4: New Orleans Saints mascot Sir Saint poses during an NFL International Series game against the Minnesota Vikings at Tottenham Hotspur Stadium.
Week 4: New Orleans Saints mascot Sir Saint poses during an NFL International Series game against the Minnesota Vikings at Tottenham Hotspur Stadium.

Safid Deen: Seahawks 27, Saints 24

I’m on the Geno Smith train, whether Andy Dalton or Jameis Winston start for the Saints.

Lance Pugmire: Seahawks 27, Saints 24

With Geno Smith posting better numbers than Russell Wilson and Rashaad Penny emerging as a fantasy darling, Seattle is in a joyous place while New Orleans needs Jameis Winston to return from his back injury following its U.K. heartbreaker.

Jarrett Bell: Saints 23, Seahawks 20

Nate Davis: Seahawks 20, Saints 17

Tyler Dragon: Saints 26, Seahawks 21

POWER RANKINGS: Week 5 NFL power rankings: Who moves up to No. 2 behind unbeaten Philadelphia Eagles?

WEEK 5 PREVIEW: NFL Week 5 matchups: Unbeaten Eagles travel to Arizona, Bengals-Ravens battle for first

IN-DEPTH: The NFL coaches project

NFL salaries: These are the highest-paid NFL players

Gannett may earn revenue from sports betting operators for audience referrals to betting services. Sports betting operators have no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See applicable operator site for its terms and conditions. If you or someone you know has a gambling problem, help is available. Call the National Council on Problem Gambling 24/7 at 1-800-GAMBLER. Must be 21 or older to gamble.

This article originally appeared on USA TODAY: Seattle Seahawks at New Orleans Saints: Game predictions, picks, odds