The jewelry designer cited irreconcilable differences in her response to the Hellboy star in a filing submitted on Monday and obtained by PEOPLE.
Stone has requested spousal support and asked that all attorney fees be paid by Perlman, the filing states. She did not list a date of separation, although Perlman listed it as May 10 in his own filing, five days before he was spotted kissing his StartUp costar, Allison Dunbar.
A rep for Perlman did not immediately respond to PEOPLE's request for comment.
The actor married Stone on Valentine’s Day in 1981. The estranged couple has two children together: daughter Blake, 36, and son Brandon, 30. The last time the two were photographed together was in April 2018.
Splash News Online Ron Perlman, Allison Dunbar
In November 2019, Perlman filed for divorce after 38 years of marriage. His petition came almost six months after he was photographed with Dunbar in late May.
In his divorce filing obtained by PEOPLE at the time, Perlman cited irreconcilable differences as the cause for divorce.
The documents stated Perlman will pay spousal support to Stone if needed and that their assets and debts will be divided as separate property, with their shared property to be determined in trial.
In April, Perlman celebrated his 70th birthday with a walk around his Los Angeles neighborhood alongside Dunbar.