An impressive run of form has seen United take first place in the table, and the Red Devils currently boast a three-point lead over champions Liverpool before Sunday’s clash on Merseyside.
Victor Lindelof comes into defence in place of Eric Bailly, while Anthony Martial is fit to start instead of Edinson Cavani in attack.
David de Gea starts in goal, while the defence reads right to left: Aaron Wan-Bissaka;Victor Lindelof, Harry Maguire, Luke Shaw.
With a tough midfield battle likely and Solskjaer wary of the threat of Mohamed Salah, Roberto Firmino and Sadio Mane, Fred and Scott McTominay provide bite in front of the defence.
Bruno Fernandes will play through the middle, with Paul Pogba and Marcus Rashford in support of Martial.
Manchester United lineup: de Gea, Wan Bissaka, Lindelof, Maguire, Shaw, Fred, McTominay, Rashford, Bruno Fernandes, Pogba, Martial
Subs: Bailly, Cavani, Mata, Greenwood, Henderson, Alex Telles, Matic, van de Beek, Tuanzebe