The Moroccan excelled in the midweek win over the same opposition and has been picked by Erik ten Hag with Sergio Reguilon, Aaron Wan-Bissaka and Lisandro Martinez absent.
The Argentine picked up a foot problem and is now expected to miss three months of action.
Ten Tag afforded a number of fringe players the chance to impress in the midweek 3-0 Carabao Cup win over the Eagles, but the likes of Marcus Rashford, Rasmus Hojlund and Bruno Fernandes are reinstated.
Mason Mount also started, upon his return from injury, and remains in the team today. Antony is back in training but not expected to play, meaning Facundo Pellistri gets the nod on the wing.
Man United XI: Onana; Dalot, Varane, Lindelof, Amrabat; Casemiro, Mount; Pellistri, Fernandes, Rashford; Hojlund
Subs: Bayindir, Evans, Maguire, Eriksen, Hannibal, McTominay, Van de Beek, Garnacho, Martial
Doubts: Eriksen, McTominay, Reguilon
Injuries: Wan-Bissaka, Shaw, Malacia, Amad, Mainoo, Martinez
Time and date: 3pm, Saturday 30 September, 2023
Venue: Old Trafford