For Villa, Dean Smith makes one change to the team that beat Everton 3-0 last weekend.
Axel Tuanzebe is unable to feature against his parent club so Kortney Hause comes in at Old Trafford for his first Premier League start of the season.
Manchester United confirmed XI: De Gea, Wan-Bissaka, Varane, Maguire, Shaw, Fred, McTominay, Greenwood, Fernandes, Pogba, Ronaldo.
Subs: Heaton, Lindelof, Martial, Lingard, Dalot, Cavani, Sancho, Matic, Van de Beek.
Aston Villa XI: Martinez, Cash, Konsa, Hause, Mings, Targett, Ramsey, Luiz, McGinn, Ings, Watkins.
Subs: Steer, Buendia, Traore, Young, Nakamba, El Ghazi, Chukwuemeka, Archer, Bogarde.