Former Red Devils winger Wilfried Zaha is in line for his full European debut for the Istanbul side, which also boasts the talents of Mauro Icardi up front.
An unbeaten start to the season has seen Gala fight from two goals down to draw with Copenhagen in their opening match of the tournament, however it was a contest they dominated only to be let down by some wayward finishing.
If confidence is high among the Turks, it is fairly flat in Manchester after a fifth defeat of the season at home to Crystal Palace on the weekend.
United lost their opening Champions League group game to Bayern Munich and must improve if they are to reach the last-16.
Date, kick-off time and venue
Manchester United vs Galatasaray is scheduled for an 8pm BST kick-off tonight, Tuesday October 3, 2023.
The match will take place at Old Trafford.
Where to watch Manchester United vs Galatasaray
TV channel: In the UK, the game will be televised live on TNT Sports 1, with coverage beginning at 7pm.
Live stream: Subscribers can also catch the contest live online via the TNT Sports app and website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog.
Manchester United vs Galatasaray team news
Man United XI: Onana; Dalot, Varane Lindelof, Amrabat; Casemiro, Mount, Hannibal; Fernandes, Hojlund, Rashford
Subs: Bayindir, Vitek, Maguire, Evans, Eriksen, McTominay, Pellistri, Antony, Garnacho, Martial
Galatasaray XI: Muslera; Boey, Sanchez, Abdulkerim, Angelino, Torreira, Kaan; Tete, Kerem, Zaha, Icardi
Subs: Gunay, Kerem, Meterns, Nelsson, Sergio, Baris, Ndombele, Bakambu
Manchester United vs Galatasaray prediction
An impressive start to the season has made Gala a dangerous team to face in this game, although Ten Hag’s strong record in the cups should show itself again at Old Trafford.
United to win, 2-1.
Head to head (h2h) history and results
Burak Yilmaz hit the winner as Gala beat United in their last meeting, some 11 years ago.
Man United wins: 2
Galatasaray wins: 1
Manchester United vs Galatasaray match odds
Man United: 4/11
Odds via Betfair (subject to change).