The centre-back was forced off with what appeared to be a hamstring injury while playing for England against Germany during the international break.
Pep Guardiola told reporters on Friday: “He is injured. He will be back when he is ready. I don't know when he will come back but I think maybe 10 days, two weeks.”
Better news for City is that Aymeric Laporte has taken part in first-team training, with the centre-back yet to play this season after undergoing knee surgery in the summer. He is closing in on a return, though this weekend has come too soon. Guardiola added: “He's training really well, trained alone when people were with the national teams.”
Kalvin Phillips is a longer-term absentee, and he faces a race to recover from shoulder surgery, but Guardiola hopes the player will be fit for the World Cup. He said: “He feels good, the surgery was good. He is getting better the mobility.
“He took the right decision, otherwise he couldn't move forward. Every training session or two three times he was out. Hopefully he can be back in time to go to the World Cup and after be back with us.”
Manuel Akanji has been impressive since arriving from Borussia Dortmund and partners Nathan Ake. Walker missed the trip to Wolves before the international break but is now fully fit again.
Erling Haaland gets his first taste of a Manchester derby, with 11 league goals to his name already. Bournemouth are the only side in either the Premier League or Champions League to stop him scoring this season.
Starting Manchester City XI: Ederson; Walker, Akanji, Ake, Cancelo; Gundogan, Silva, De Bruyne; Foden, Grealish, Haaland.