The Red Devils switched formations for the 2-2 draw at Aston Villa amid the absence of Ronaldo due to injury, with Ralf Rangnick potentially set to stick with a 4-3-3 system here.
The Portuguese veteran is hoped to shake off a hip issue in time for the game in West London, having stopped off in Switzerland on Monday to accept a Special Award at Fifa’s The Best ceremony.
Rashford (thigh) is on the bench while Luke Shaw and Scott McTominay are back from one-game bans although only the latter starts.
“Cristiano and Marcus were training yesterday, so we will train today,” Rangnick explained on Tuesday. “But in the press conference before the Villa game, I was also convinced Cristiano would be available and he wasn't.
“So we have to wait for the training session today in an hour's time. I think they both could be available.”
Eric Bailly (AFCON) and Paul Pogba (hip) are both out with Aaron Wan-Bissaka (illness) a doubt. Anthony Martial was said by the interim manager to have refused to travel to the Villa draw following a knee injury - something the striker has publicly denied. The issue is now dealt with, according to Rangnick.
Victory for United will propel them as high as fifth in the Premier League table after only one win in their last four league games.
Starting Man United XI (4-3-3): De Gea; Dalot, Lindelof, Varane, Telles ; McTominay, Fernandes, Fred; Greenwood, Elanga, Ronaldo.