The Blues are favourites for the WSL crown with a two-point advantage over City - plus a game in hand - while Manchester United are also in the picture.
City had clocked up four wins in a row before suffering an FA Cup exit at the hands of Aston Villa in their last game.
But a recent WSL victory over title rivals Arsenal has given them confidence of a tilt at the trophy, but first they must avenge a 2-0 defeat to Chelsea back in west London earlier in the campaign.
Where to watch Man City vs Chelsea
TV channel: In the UK, the game is available to watch free-to-air via BBC One, with coverage starting at 12.25pm for a 12.40pm GMT kick-off.
Live stream: The match will be broadcast for free on the BBC iPlayer app and website.