A new report has brought to the fore the need for greater accountability in South Africas environment and waste management.
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She was formally recognised by the State of Israel for her bravery in harbouring a Jewish mother and some of her children from the Nazis.
New Delhi [India], April 10 (ANI): The holy month of Ramadan is approaching and with it, a new wave of festive cheer will be observed. It is the ninth month of the Islamic calendar and is celebrated by people belonging to the Muslim community all around the world.
Gun salutes were held on the UK’s Royal Navy vessels and in areas across the United Kingdom, on Saturday, April 10, to mark the death of Prince Philip at the age of 99.The Ministry of Defence released footage of the frigate HMS Montrose performing a 41 gun salute in Duqm, Oman.The BBC said 41 gun salutes were fired by ceremonial 3lb guns at Portsmouth and Devonport Naval Bases and aboard destroyer HMS Diamond in UK waters.Batteries fired 41 rounds at one round every minute from midday in cities including London, Edinburgh, Cardiff and Belfast, as well as Royal Navy warships, the Evening Standard reported. Credit: Ministry of Defence via Storyful
A study by Brigham and Women's Hospital found that more than 1 in 3 new mothers surveyed had significant levels of depression. Prior to the pandemic, rates of perinatal depression were about 15% to 20%.
Events and reaction from around the world to mark the death of Prince Philip at age 99: LONDON — The Twitter account of Britain's royal family has featured a tribute Queen Elizabeth II gave to Prince Philip for the couple's 50th wedding anniversary. An excerpt from a speech the queen made in 1997 was posted Saturday, the day after Philip died at age 99. “He has, quite simply, been my strength and stay all these years, and I, and his whole family, and this and many other countries, owe him a debt greater than he would ever claim, or we shall ever know,” Elizabeth said of her husband in the anniversary speech. Philip also had words of gratitude for his wife and monarch at the time. “I think the main lesson that we have learnt is that tolerance is the one essential ingredient of any happy marriage,” he said. “You can take it from me that the queen has the quality of tolerance in abundance.” A portrait of of the couple taken by photographer Anne Leibovitz and first released in 2016 on Philip’s 95th birthday accompanied Saturday's Twitter post. ___ PRINCE PHILIP DIES AT 99 The United Kingdom and members of the Commonwealth of nations that includes the former territories of the British Empire are remembering Prince Philip, the irascible and tough-minded husband of Queen Elizabeth II. Philip died Friday at age 99 after more than seven decades of supporting his wife in her public duties. More coverage: — Prince Philip, husband of Queen Elizabeth II, dies at 99 — Military salutes honour former naval officer Philip with 41 guns — BBC invites viewers to say whether coverage was excessive. — For AP’s full coverage of the death of Prince Philip go to https://apnews.com/hub/prince-philip ___ BEIJING — The presidents of China and South Korea have joined other world leaders in offering their condolences to the widowed Queen Elizabeth II. Chinese President Xi Jinping and his wife, Peng Liyuan, have sent their “deep condolences” to the British monarch on the passing of her husband, Prince Philip, the official Xinhua News Agency reported. South Korean President Moon Jae-in used Twitter to express his “heartfelt thoughts” about Philip’s death at age 99 on Friday. Moon tweeted on Saturday that South Koreans will “forever remember” the contribution Philip made to friendly ties between their country and the U.K. when he visited with Queen Elizabeth II in 1999. “I offer my condolences and share the grief with the bereaved family and the people of the United Kingdom,” he said. ___ LONDON — Prince Andrew and Prince Edward visited Queen Elizabeth II at Windsor Castle on Saturday following the death of her husband and their father, Prince Philip. Edward and Sophie, the Countess of Wessex, spent around an hour at the castle. She told reporters “the queen has been amazing” as the couple left Windsor in a Land Rover. Andrew waved at crowds as he left. Prince Charles, the queen’s oldest child and heir to the throne, visited his mother on Friday. In a tribute program aired by the BBC on Friday. all four of Philip’s children remembered him as someone who had encouraged and supported them. Charles described his father’s life as an “astonishing achievement” while Edward said his father had a tough job that was carried out with the most “extraordinary flare.” ___ LONDON — Gun salutes have started across the U.K., in Commonwealth countries and at sea to honour Britain’s Prince Philip, who died at age 99 on Friday. Military leaders assigned batteries of cannons and guns to pay tribute to the former naval officer and husband of Queen Elizabeth II. In London, Edinburgh, Cardiff and Belfast, teams fired 41 rounds at one-minute intervals starting at midday on Saturday. The Australian Defence Force offered its salute at 5 p.m. local time outside Parliament House in Canberra. New Zealand planned to give an artillery tribute on Sunday. Members of the public left flowers outside Buckingham Palace and Windsor Castle on Saturday, ignoring appeals from authorities and the royal family to refrain from gathering because of the COVID-19 pandemic. ___ VATICAN CITY — Pope Francis has offered Queen Elizabeth II “heartfelt condolences” for the loss of her husband and praised the late Prince Philip for his devotion to marriage and “distinguished record” of public service. In a telegram sent by the Vatican’s secretary of state and made public on Saturday, Francis said he was “saddened” to learn of Philip’s death on Friday at age 99. “Recalling Prince Philip’s devotion to his marriage and family, his distinguished record of public service and his commitment to the education and advancement of future generations, His Holiness commends him to the merciful love of Christ our Redeemer,” read the telegram sent in the pontiff’s name. “Upon you and upon all who grieve his loss in the sure hope of the resurrection, the Holy Father invokes the Lord’s blessings of consolation and peace,” the message concluded. ___ LONDON — Gun salutes marking the death of the Duke of Edinburgh will take place across the U.K., in Gibraltar and at sea. The U.K. defence ministry said that batteries will fire 41 rounds at one round every minute from midday in cities including London, Edinburgh, Cardiff and Belfast, as well as Gibraltar and from Royal Navy warships. Gun salutes also marked the deaths of Queen Victoria in 1901 and Winston Churchill in 1965. Authorities are encouraging to watch the gun salutes online or on television from home amid the coronavirus pandemic. Prince Philip died Friday at age 99. ___ LONDON — The U.K.’s national broadcaster switched instantly into mourning mode when Prince Philip’s death was announced, . The BBC cancelled its regular programming and aired special coverage about Philip hosted by black-clad news anchors on Friday. Popular prime-time shows such as the cooking contest “MasterChef” were pulled off the air, and the network’s music radio stations played instrumentals and sombre tunes. Some Britons saw the BBC’s actions as a fitting mark of respect. For others, it was a bit much. The broadcaster has received so many complaints alleging its reporting was excessive that it set up a special page on its website for viewers to register objections if they felt there was “too much TV coverage of the death of HRH Prince Philip, Duke of Edinburgh.” The publicly funded BBC often finds itself criticized from all sides over its treatment of major national events. When the Queen Mother Elizabeth died in 2002, the broadcaster was criticized because the announcer delivering the news did not wear a black tie. ___ LONDON — Mourners are leaving flowers again in front of Buckingham Palace and Windsor Castle, a day after Prince Philip’s death. Small groups of people gathered Saturday morning near the front gates of Buckingham Palace, where the Union Jack flies at half-staff. Earlier, the flowers left there on Friday had been removed and were placed in the back of a van. Palace officials have been encouraging people not to come to Buckingham Palace or Windsor Castle to leave flowers amid the coronavirus pandemic. ___ PORT VILA, Vanuatu — A tribe in the remote island nation of Vanuatu who saw Prince Philip as a god will greet his death with ritual wailing and ceremonial dancing, an expert said. The group, based in villages on the island of Tanna in the former Anglo-French colony, revered the Duke of Edinburgh and believed him to be a reincarnation of an ancient warrior who left the island to fight a war. ___ DHARAMSHALA, India — The Dalai Lama has expressed his condolences over the death of Prince Philip in letter to Queen Elizabeth II and Prince Charles. In his letter to the queen he said: “I am sorry to learn the sad news that your husband, H.R.H. Prince Philip, Duke of Edinburgh has passed away. I will pray for him and offer my condolences to Your Royal Highness and your family at this sad time. “As we all remember him, we can rejoice that he lived a meaningful life.” He wrote to Prince Charles: “As someone who counts you as a dear, respected friend, I would also like to offer my condolences to Your Royal Highness and your family.” ___ WELLINGTON, New Zealand — New Zealand Prime Minister Jacinda expressed her country’s sorrow at the death of Prince Philip. “Our thoughts are with Her Majesty the Queen at this profoundly sad time,” she said. Ardern said Philip will be fondly remembered for the encouragement he gave to many young New Zealanders through The Duke of Edinburgh’s Hillary Award. “In over 50 years of the award in New Zealand, thousands of young people have completed life-changing challenges through the program,” she said. Ardern directed that all flags on government buildings and naval vessels be flown at half-staff. She said a national memorial service will be held in New Zealand’s capital, Wellington. ___ JAKARTA, Indonesia — Indonesian President Joko Widodo expressed deep condolences at the death of Prince Philip. Widodo tweeted: “My deepest condolences on the passing of HRH Prince Philip, the Duke of Edinburgh. Our thoughts and prayers are with Her Majesty Queen Elizabeth II, the Royal Family and the British people in this time of sorrow." ___ SYDNEY — Australian Prime Minister Scott Morrison offered his country’s “deepest sympathies and condolences” to Queen Elizabeth II on the passing of Prince Philip. “While your strength and stay, your Majesty, may now have passed, Jenny and I pray that you will find great comfort in your faith, in your family, at this time,” he said. “But we also, your Majesty, say to you as a Commonwealth, let us also now be your strength and stay as you continue to endure, as you continue to serve so loyally and so faithfully, as you have done over so many generations.” He added: “She has been there for us over such a long time, let us be there now for you, your Majesty, and allow us to send our love to you on this, I’m sure, one of your most sad of days.” In Canberra, the national flag was lowered to half-mast over Parliament House. ___ MANILA, Philippines — Philippine President Rodrigo Duterte has expressed his deep condolences to Queen Elizabeth II for the death of Prince Philip in a public message where his government cited its strong ties with the United Kingdom. “We pray for the eternal repose of his soul and for The Royal Family to find strength in this time of mourning,” Duterte said in message issued by his spokesman, Harry Roque. “The Philippines and the United Kingdom have strong bilateral ties and we share the grief of the British people in this period of bereavement,” Duterte’s message said. Duterte has repeatedly lashed at European countries in the past for raising alarm over his deadly crackdown against illegal drugs which has left thousands of mostly petty suspects dead. The UK was one of 18 countries that approved a United Nations Human Rights Council resolution in 2019 which called for an inquiry into human rights conditions in the Philippines amid Duterte’s bloody crackdown, sparking condemnations from his administration. ___ KUALA LUMPUR, Malaysia — Malaysian Prime Minister Muhyiddin Yassin said the world has lost a “towering figure” with the passing of Prince Philip. In a tribute post on his Facebook, Muhyiddin said the prince had visited Malaysia several times and was always a “friend of our country.” The Duke of Edinburgh International award introduced in 2000 that had recognized thousands of Malaysian youths for their achievements in community, sports and adventure activities was among the prince’s many contributions, Muhyiddin said. “The Duke of Edinburgh will be sadly missed; his passing marks the end of a life spent in selfless service to the greater good,” the premier said. The Associated Press
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Ontario's alcohol and gaming regulator says it has suspended the liquor licence of a Kemptville, Ont., restaurant after an anti-mask event was held on the premises during the province's third COVID-19 lockdown. The Alcohol and Gaming Commission of Ontario says it has issued an interim suspension to the South Branch Bistro for "reasons of public interest and safety," as well as a notice of proposal to revoke the eatery's liquor licence altogether. The AGCO says its officials and members of the Ontario Provincial Police visited the restaurant during a scheduled event dubbed a "No More Lockdown" protest on Thursday. A statement from the commission says patrons were consuming alcohol indoors, on the patio and in the surrounding parking lot, noting most present including staff were unmasked and not maintaining physical distance. Upon returning to the restaurant on Friday, the AGCO says they saw its patio was still open for business and staff were not wearing masks. Under the terms of a provincewide stay-at-home order that took effect on Thursday, restaurants are banned from offering in-person dining and can only provide takeout or delivery service. "Those who hold a licence to sell alcohol are responsible for meeting their obligations under the (Liquor Licence Act) and to act with honesty and integrity," the AGCO said in its statement. Licence holders who do not meet the requirements of the LLA can face fines and see their liquor licence temporarily suspended or revoked. The South Branch Bistro event on Thursday was held with support from Ontario legislator Randy Hillier, an independent MPP and vocal critic of the province's lockdown measures. "Lockdowns have taken a massive toll on our mental health, bank account and livelihoods," the restaurant said in a Facebook post ahead of the protest. "We were faced with two choices - stay open to feed our family, or close for good. We opted for the former than the latter." This report by The Canadian Press was first published April 10, 2021. The Canadian Press
Several thousand people blocked traffic in front of the Serbian parliament on Saturday in a protest against lack of government action to prevent water, land and air pollution by industries such as the mining sector. Protesters, who came to Belgrade from all over Serbia, held banners reading "Cut corruption and crime not forests," and "Young people are leaving because they cannot breathe". In recent years Serbia has started selling its mining resources to foreign companies, despite opposition by local residents who had warned that increased ore exploration could cause greater pollution.
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This is the latest case in which the high court has barred officials from enforcing coronavirus-related restrictions applying to religious gatherings.
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Gun salutes have been fired across the UK to mark the death of the Duke of Edinburgh at the age of 99.
The former India all-rounder has called on his followers to follow the stump mic.
MANCHESTER, England — Manchester City’s march to the Premier League title was halted by a 2-1 loss to 10-man Leeds on Saturday, with Stuart Dallas scoring the winner in second-half stoppage time for his second goal of the game. Reduced to 10 men moments before halftime because of Liam Cooper’s straight red card, Leeds spent almost the entire second half camped inside its own area repelling wave after wave of attacks by City. The runaway leaders finally got rewarded for their pressure with an equalizer by Ferran Torres in the 76th minute but Dallas, who had put Leeds in front in the 42nd, burst through a gap in City’s defence and slid a finish past goalkeeper Ederson for a stunning winning goal on a breakaway. City’s dominance showed in the stats — Pep Guardiola’s team had 29 shots compared to Leeds’ two — but that didn’t translate into one of the four wins needed to regain the league trophy. City, which is 14 points clear of second-place Manchester United, still requires a maximum of 11 points. It was a fourth defeat in the league, three of them coming at home, as Guardiola lost to a team coached by his mentor, Marcelo Bielsa. Cooper’s sending-off turned what had been an end-to-end game into one resembling a training-ground exercise of attack vs. defence. Referee Andre Marriner initially showed the Scotland international a yellow card for a tackle that saw him get the ball but follow through, with his studs showing, into the leg of Gabriel Jesus. As a result, City centre back John Stones spent most of the second half on the edge of Leeds’ penalty area and right back Joao Cancelo as a right winger. Leeds, one of the Premier League’s flair teams, demonstrated unlikely resilience to hold off City until Torres’ goal 14 minutes from time, which came from a through ball from Bernardo Silva. But the visitors had the final say as Dallas ran onto a pass from Ezgjan Alioski, pierced the centre of City’s defence and beat Ederson. “Against these teams, you don’t get chances so you need to be clinical," Dallas said. “I think I took one touch and closed my eyes.” City ultimately paid the price for its heavy rotation that saw Guardiola make seven changes for a match that came in between the two legs against Borussia Dortmund in the Champions League quarterfinals. Kevin De Bruyne was an unused substitute. There was a two-minute silence before the game to honour Prince Philip, the husband of Queen Elizabeth II, who died on Friday at the age of 99. Players wore black armbands and flags at the stadium were lowered to half-staff. ___ More AP soccer: https://apnews.com/hub/soccer and https://twitter.com/AP_Sports The Associated Press
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Bills lineman Cody Ford was fined for this block, which NFL officials now say is perfectly legal.
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TH1902 anti-tumor post-treatment effect persists longer than with docetaxel aloneMONTREAL, April 10, 2021 (GLOBE NEWSWIRE) -- Theratechnologies Inc. (Theratechnologies) (TSX: TH) (NASDAQ: THTX), a biopharmaceutical company focused on the development and commercialization of innovative therapies, today announced that new in vivo preclinical data were presented at the 2021 Annual Meeting of the American Association for Cancer Research (AACR). These data demonstrated sustained tumor regression, better anti-tumor activity and tolerability with TH1902 compared to docetaxel alone in all cancer types studied, namely melanoma, pancreatic, ovarian, endometrial, colorectal and triple-negative breast cancers. The anti-tumor effect of TH1902 persisted longer post-treatment than with docetaxel alone. TH1902 is the Company’s lead investigational peptide-drug conjugate (PDC) derived from its SORT1+ Technology™. “The FDA fast-track designation for TH1902 was supported by the data presented today. This designation is a significant recognition of our SORT1+ Technology™ as very few investigational therapies receive fast track designation based on preclinical data. It strongly endorses TH1902 as a potentially new and innovative treatment for all patients with sortilin positive (SORT1+) solid tumors that are refractory to standard therapy. The Phase 1 clinical trial is now underway and we look forward to advancing TH1902 through further stages of its development,” said Dr. Christian Marsolais, Senior Vice President and Chief Medical Officer, Theratechnologies. AACR Poster #1313 – TH1902, a docetaxel peptide-drug conjugate, shows pre-clinical efficacy in several SORT1+ cancersHighlights of the poster include new data on TH1902 in melanoma, where the sortilin receptor is expressed in over 90% of cases. TH1902 was associated with superior anti-tumor effect and sustained post-treatment effect compared to docetaxel alone. Other highlights of this poster include better and sustained anti-tumor effect in pancreatic tumors, where sortilin is expressed in 30% to 50% of cases and in triple-negative breast cancer, where sortilin is expressed in almost 60% of cases. Treatment effect was also observed with TH1902 in colorectal cancer, which is encouraging as docetaxel is not recognized as standard of care due to lack of response in this cancer. The positive effect of TH1902 on tumor regression was also observed in these cancer types at an equimolar quarter dose compared to docetaxel alone. Only registered attendees can access the poster. AACR Poster #1439 – Increasing potency of anticancer drugs through SORT1+ Technology™: A new targeted approach for treatment of ovarian and endometrial cancers New data presented in this poster demonstrated sustained inhibition of ovarian and endometrial cancers with TH1902 at equimolar doses of docetaxel alone. Specifically, TH1902 showed improved anti-tumor activity in endometrial cancer at an equimolar quarter doses compared to docetaxel alone. Sortilin is expressed in over 90% of ovarian and endometrial cancers, making it an excellent target for drug development. Ovarian and endometrial cancers have poor prognosis and survival outcomes. Sortilin expression increases as a function of tumor grade (I to IV) and is associated with poor prognosis and decreased survival in different cancers. Only registered attendees can access the poster. Absence of neutropenia with TH1902Neutropenia was absent after six consecutive treatments with TH1902 at an equivalent dose of the maximum tolerated dose (MTD) of docetaxel, whereas a single treatment of docetaxel strongly reduced neutrophil counts. Neutropenia increases susceptibility to develop infections. Several cancer treatments are known to cause neutropenia and require on and off treatment cycles to avoid the potentially severe consequences of infections associated with the onset of neutropenia. Phase 1 clinical trial of TH1902The Phase 1 dose-escalating study is evaluating the safety, pharmacokinetics, maximum tolerated dose (MTD) and preliminary anti-tumor activity of TH1902 administered once every three weeks in patients with advanced solid tumors refractory to available anti-cancer therapies. Once the MTD is determined, it is planned that a total of 40 additional patients will be enrolled to evaluate the potential anti-tumor activity of TH1902 in patients with endometrial, ovarian, colorectal, pancreatic and triple negative breast cancers. The detailed Phase 1 study protocol is available at ClinicalTrials.gov under the identifier number: NCT04706962. About TH1902TH1902 combines Theratechnologies’ proprietary peptide to docetaxel. This PDC is the lead candidate derived from Theratechnologies’ SORT1+ Technology™ in oncology. The Canadian Cancer Society and the Government of Quebec, through the Consortium Québécois sur la découverte du médicament (CQDM), will contribute a total of 1.4 million dollars towards some of the research currently being conducted for the development of Theratechnologies’ targeted oncology platform at the molecular oncology laboratory of Dr Borhane Annabi at the Université du Québec in Montréal (UQAM). About SORT1+ Technology™ Theratechnologies has developed a peptide which specifically targets sortilin (SORT1) receptors. SORT1 is expressed in ovarian, triple negative breast, skin, lung, colorectal and pancreatic cancers, among others. SORT1 plays a significant role in protein internalization, sorting and trafficking, making it an attractive target for drug development. Commercially available anticancer drugs, like docetaxel, doxorubicin or tyrosine kinase inhibitors are conjugated to Theratechnologies’ investigational novel peptide to specifically target sortilin receptors. This could potentially improve the efficacy and safety of those agents. About Theratechnologies Theratechnologies (TSX: TH) (NASDAQ: THTX) is a biopharmaceutical company focused on the development and commercialization of innovative therapies addressing unmet medical needs. Further information about Theratechnologies is available on the Company's website at www.theratech.com, on SEDAR at www.sedar.com and on EDGAR at www.sec.gov. Forward-Looking Information This press release contains forward-looking statements and forward-looking information, or, collectively, forward-looking statements, within the meaning of applicable securities laws, that are based on our management’s beliefs and assumptions and on information currently available to our management. You can identify forward-looking statements by terms such as "may", "will", "should", "could", “would”, "outlook", "believe", "plan", "envisage", "anticipate", "expect" and "estimate", or the negatives of these terms, or variations of them. The forward-looking statements contained in this press release include, but are not limited to, statements regarding the development of TH1902 for the potential treatment for all patients with sortilin positive (SORT1+) solid tumors that are refractory to standard therapy, and the determination of the MTD. Forward-looking statements are based upon a number of assumptions and include, but are not limited to, the following: pre-clinical in vivo results will be replicated in humans during the Phase 1 trial, we will be able to determine the MTD, we will be able to enroll patients for the Phase 1 trial, treatment with TH1902 will be efficacious and safe in various types of cancer and no serious adverse side effects will be discovered from the administration of TH1902 to patients. Forward-looking statements are subject to a variety of risks and uncertainties, many of which are beyond our control that could cause our actual results to differ materially from those that are disclosed in or implied by the forward-looking statements contained in this press release. These risks and uncertainties include, among others, the risk that the Covid-19 pandemic will materially adversely affect the conduct of our Phase 1 trial, we are unable to determine the MTD, results obtained from the administration of TH1902 do not allow the pursuit of additional clinical trials, patients die and such death is related to the administration of TH1902 resulting in the abandonment of our Phase 1 trial, discovery of serious adverse side effects also leading to the abandonment of the Phase 1 trial, difficulty in recruiting patients leading to delays in initiating or completing the Phase 1 trial and non-performance by our third-party contract suppliers of their covenants, obligations or undertakings under the terms of our agreements with them. We refer potential investors to the "Risk Factors" section of our annual information form dated February 24, 2021 available on SEDAR at www.sedar.com and on EDGAR at www.sec.gov as an exhibit to our report on Form 40-F dated February 25, 2021 under Theratechnologies’ public filings for additional risks regarding the conduct of our business and Theratechnologies. The reader is cautioned to consider these and other risks and uncertainties carefully and not to put undue reliance on forward-looking statements. Forward-looking statements reflect current expectations regarding future events and speak only as of the date of this press release and represent our expectations as of that date. We undertake no obligation to update or revise the information contained in this press release, whether as a result of new information, future events or circumstances or otherwise, except as may be required by applicable law. For media inquiries:Denis BoucherVice President, Communications and Corporate Affairs514email@example.com For investor inquiries:Leah GibsonSenior Director, Investor Relations617firstname.lastname@example.org
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