The right-back has not played since injury his hamstring in the win over Aston Villa almost four weeks ago but has since returned to training, with Joe Gomez deputising since. It is a huge boost for Jurgen Klopp.
Thiago Alcantara is not available, while Stefan Bajcetic has suffered a setback.
Dominik Szoboszlai returns to the XI after a match-winning cameo against Leicester in the Carabao Cup, scoring his team’s second goal - a stunning long-range effort - as Liverpool came from behind to win 3-1. Diogo Jota also scored, but drops to the bench in London.
Luis Diaz, Cody Gakpo and Mohamed Salah make up the front three.
Confirmed team news
Tottenham XI: Vicario; Pedro Porro, Romero, Van de Ven, Udogie; Sarr, Bissouma; Kulusevski, Maddison, Son; Richarlison
Subs: Forster, Royal, Davies, Phillips, Hojbjerg, Skipp, Solomon, Velez, Donley
Liverpool XI: Alisson; Gomez, Konaté, Van Dijk, Robertson; Szoboszlai, Mac Allister, Jones; Salah, Gakpo, Luis Diaz
Subs: Kelleher, Endo, Konate, Nunez, Elliott, Jota, Tsimikas, Gravenberch, Alexander-Arnold
Injuries: Thiago, Bajcetic, Bradley
Time and date: 5.30pm, Saturday 30 September, 2023
Venue: Tottenham Hotspur Stadium