It was a European night to forget for Leicester, as the Foxes lost 2-0 at home to Slavia Prague and were swiftly eliminated.
Brendan Rodgers will hope that his team can bounce back and perform in the league, and a win could close the gap on Manchester City and send Leicester above Manchester United.
Here is everything you need to know:
When is it?
The fixture will kick-off at 12pm at the King Power Stadium.
How can I watch it?
The match is live on BT Sport 1, with coverage starting from 11:30am.
What is the team news?
Leicester trio Harvey Barnes, Ricardo Pereira and Timothy Castagne are all set to return to the squad after missing the midweek loss in the Europa League. James Maddison is out due to a hip issue, joining James Justin, Dennis Praet, Ayoze Perez, Wes Morgan and Wesley Fofana on the sidelines.
Thomas Partey returned in the Europa League win over Benfica following his hamstring injury and Rob Holding has recovered from a concussion to give Mikel Arteta a full complement of players.
Leicester: Schmeichel, Castagne, Evans, Soyuncu, Thomas, Pereira, Ndidi, Tielemans, Barnes, Iheanacho, Vardy
Arsenal: Leno, Cedric, Luiz, Mari, Tierney, Xhaka, Elneny, Pepe, Smith Rowe, Willian, Lacazette
Leicester City: 6/4
Arsenal are on a high – but players like Bukayo Saka surely need a rest. Leicester have been the better side domestically, and the Gunners can never seem to contain Jamie Vardy. I expect the striker to score. 2-1 Leicester.