Jacksonville Jaguars at Los Angeles Chargers: Predictions, picks and odds for NFL Week 3 matchup

Riding high off a 24-0 shutout against the Indianapolis Colts, Trevor Lawrence's Jacksonville Jaguars travel to Los Angeles to face Justin Herbert and the Chargers.

Can Lawrence, Christian Kirk and the Jaguars offense repeat their Week 2 sucess? Or will Herbert, Austin Ekeler, Mike Williams and the Chargers rebound after a Thursday Night Football loss to the Kansas City Chiefs? The game is scheduled to kick off Sunday at 4 p.m. ET from SoFi Stadium.

Here's a look at the betting details and USA TODAY's NFL staff picks for the Jaguars vs. Chargers Week 3 game:

Jaguars at Chargers odds, moneyline and over/under

'SELLING THE RUN': Jaguars rely on running threat to open up offense

INJURY UPDATE: Chargers QB Justin Herbert listed as questionable vs. Jaguars

POWER RANKINGS: Bills, Chiefs remain 1-2, but Dolphins among two new teams in top five

NFL Week 3 odds, predictions and picks

Steelers vs. Browns | Saints vs. Panthers | Texans vs. Bears | Chiefs vs. Colts | Bills vs. Dolphins | Lions vs. Vikings | Ravens vs. Patriots | Bengals vs. Jets | Raiders vs. Titans | Eagles vs. Commanders | Jaguars vs. Chargers | Rams vs. Cardinals | Falcons vs. Seahawks | Packers vs. Buccaneers | 49ers vs. Broncos | Cowboys vs. Giants

Lorenzo Reyes: Chargers 21, Jaguars 17

Obviously, the status of Justin Herbert will be the key indicator here. I like L.A. to win, but Jacksonville could use its shutout against the Colts as a bit of a springboard. And with Herbert at least slightly hobbled, the line is just a bit too rich for me.

Justin Herbert threw for 279 yards and three touchdowns in the Chargers' win over the Raiders.
Justin Herbert threw for 279 yards and three touchdowns in the Chargers' win over the Raiders.

Safid Deen: Chargers 30, Jaguars 17

Justin Herbert’s pain tolerance will be tested again in his first real start since suffering a rib cartilage injury against the Chiefs. Herbert was unable to extend himself to run a yard for a first down but was able to throw a 35-yard strike into the red zone one play later. He’ll help the Chargers take an early lead over Trevor Lawrence and the Jaguars, who will struggle on the road as they did in Week 1 at Washington.

Lance Pugmire: Chargers 30, Jaguars 17 

As of early this week, the expected return of quarterback Justin Herbert makes Los Angeles more than a touchdown favorite, and the over-under is 47.5. That changes if Chase Daniel has to start, especially against a unit that blanked the Colts Sunday.

Jarrett Bell: Chargers 27, Jaguars 23

Nate Davis: Chargers 30, Jaguars 22

Tyler Dragon: Chargers 28, Jaguars 20

RANKING PLAYOFF VIABILITY: Which NFL teams can survive 0-2 start to 2022 season?

NFL NEWS, DELIVERED: Breaking news, in-depth analysis delivered to your inbox. Sign up here!

SEASON PREDICTIONS: Super Bowl 57, playoffs, MVP and other awards

NFL salaries: These are the highest-paid NFL players

Gannett may earn revenue from sports betting operators for audience referrals to betting services. Sports betting operators have no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See applicable operator site for its terms and conditions. If you or someone you know has a gambling problem, help is available. Call the National Council on Problem Gambling 24/7 at 1-800-GAMBLER. Must be 21 or older to gamble.

This article originally appeared on USA TODAY: Jacksonville Jaguars at Los Angeles Chargers predictions, picks for NFL Week 3