Desalting and Buffer Exchange Market Size to Reach USD 1,691.9 Million in 2028; CAGR of 10.3% -- Reports And Data

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Increasing focus on proteomics and genomics research, rising need to separate monoclonal antibodies from impurities, and growing application of chromatography technique across various end-use industries are key factors driving market growth

New York, New York--(Newsfile Corp. - April 22, 2021) - The global desalting and buffer exchange market size is expected to reach USD 1,691.9 Million in 2028 at a CAGR of 10.3%, according to the latest report by Reports and Data. Increasing investment in biopharmaceutical sector, growing demand and production of monoclonal antibodies, and rising focus on proteomics and genomics research are key factors expected to drive market revenue growth over the forecast period. Increasing importance of buffer exchange in biological sample preparation and purification is also a key factor driving market revenue growth. Advancements in molecular chemistry and increasing application of chromatography techniques across various end-use industries are other major factors expected to drive market revenue growth over the forecast period.

Market Size - USD 827.05 Million in 2020, Market Growth - at a CAGR of 10.3%, Market Trends - Growing application of desalting and buffer exchange in antibody purification

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Desalting is a process which removes salts and other impurities from a sample while buffer exchange is carried to replace the buffer system used with another more appropriate for specific downstream applications. Desalting and buffer exchange are chiefly based on gel filtration chromatography. These methods aim to recover components of a sample in buffer systems used to pre-equilibrate the small and porous polymer beads. Desalting removes phenol or unincorporated nucleotides from nucleic acids, salts from protein solutions, and excess labeling agents from conjugated proteins. Buffer exchanged replaces the old buffer system with the one appropriated for downstream applications such as electrophoresis, ion exchange, or affinity chromatography. Desalting and buffer exchange also aim to separate monoclonal antibodies and other biological therapeutics from impurities and this is expected to drive market growth over the forecast period.

Increasing demand for pure monoclonal antibodies to develop efficient therapeutic approaches to cater to growing unmet medical demand across the globe is expected to drive market growth over the forecast period. In addition, expiration of patented drugs and growing opportunities for generic drug production in developing regions is also expected to contribute to revenue growth of the market over the forecast period. However, lack of skilled professionals and high costs associated with experiments are expected to restrain market growth to an extent over the forecast period.

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Some Key Highlights From the Report:

  • Kits segment revenue is expected to expand significantly over the forecast period owing to increasing demand for desalinating kits in preparation of protein samples, growing use of kits in SDS-PAGE and mass spectrophotometry, and rising need to separate monoclonal antibodies from impurities.

  • Efficient ultrafiltration process is necessary for achieving highly concentrated mAb solutions on a large-scale and this is expected to contribute to revenue growth of filtration segment over the forecast period. In addition, minimal costs, various benefits of ultrafiltration, and increasing demand for monoclonal antibodies are key factors expected to further fuel revenue growth of this segment over the forecast period.

  • Bioprocess segment is expected to account for a considerable revenue growth over the forecast period owing to increasing demand for biological therapeutics, rapid development of bioprocessing, and growing demand for efficient sample preparation and purification.

  • Asia Pacific market revenue is expected to expand significantly over the forecast period owing to rapidly expanding biopharmaceutical sector, rising penetration of clinical research organizations, and increasing R&D in biotechnology sector.

  • Major companies operating in the market include Thermo Fisher Scientific, Inc., Merck AG, GE Healthcare, Danaher Corporation, Sartorius, Agilent Technologies, Inc., VWR International LLC, Bio-works Technologies AB, Bio-Rad Laboratories, and Norgen Biotek Corp.

  • In April 2020, Pall Corporation, which is a leading company offering solutions in filtration, separation, and purification, unveiled next-generation of its lab-scale tangential flow filtration (TFF) solutions. The system, known as Minimate EVO TFF system, is convenient to use and aims to streamline lab-scale concentration, desalting, and buffer exchange workflows.

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For the purpose of this report, Reports and Data has segmented the global desalting and buffer exchange market based on product, technique, application, and region:

Product Outlook (Revenue, USD Million; 2018-2028)

  • Kits

  • Cassettes & Cartridges

  • Spin Columns

  • Others

Technique Outlook (Revenue, USD Million; 2018-2028)

  • Filtration

    • Ultrafiltration

    • Dialysis

  • Chromatography

    • Size exclusion chromatography

    • Other chromatography techniques

  • Precipitation

Application Outlook (Revenue, USD Million; 2018-2028)

  • Bioprocess Application

  • Diagnostic Application

Regional Outlook (Revenue, USD Million; 2018-2028)

  • North America

    • U.S.

    • Canada

    • Mexico

  • Europe

    • Germany

    • U.K.

    • Italy

    • France


    • Rest of Europe

  • Asia Pacific

    • China

    • India

    • Japan

    • South Korea

    • Rest of APAC

  • Latin America

    • Brazil

    • Rest of LATAM

  • Middle East & Africa

    • Saudi Arabia

    • U.A.E.

    • South Africa

    • Rest of MEA

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