The much-anticipated event is headlined by undefeated middleweight king Adesanya’s attempts to become a two-division world champion as he moves up to take on Polish light-heavyweight title-holder Jan Blachowicz.
‘Stylebender’ would follow in the footsteps of the dominant Nunes - as well as the likes of Conor McGregor - if he was able to hold two UFC world titles simultaneously, though has been warned that he faces potentially his toughest test in mixed martial arts to date on Saturday.
As for Nunes, the reigning women’s bantamweight and featherweight champion - and greatest female fighter ever to grace the octagon - puts the latter belt on the line against former Invicta FC champion Megan Anderson.
If that wasn’t quite enough, Russia’s Yan also defends his men’s bantamweight crown for the very first time in an evenly-matched battle against top contender Aljamain Sterling.
UFC 259 TV channel and live stream
TV channel: In the UK, UFC 259 is being broadcast live on BT Sport 2, with coverage of the prelim fights beginning at 1am GMT on Sunday morning.
The main card should begin at around 3am, depending on the length of those prelim bouts, with Adesanya vs Blachowicz not expected to start until at least 5am.
The early prelim fights are available to watch for fans with a UFC Fight Pass subscription.
Live stream: Those with a BT Sport subscription can also stream the action online via the BT Sport website or app.
UFC 259 card in full
Jan Blachowicz (c) vs Israel Adesanya (for the men’s light-heavyweight title)
Amanda Nunes (c) vs Megan Anderson (for the women’s featherweight title)
Petr Yan (c) vs Aljamain Sterling (for the men’s bantamweight title)
Islam Makhachev vs Drew Dober (men’s lightweight bout)
Thiago Santos vs Aleksandar Rakic (men’s light-heavyweight bout)
Dominick Cruz vs Casey Kenney (men’s bantamweight bout)
Song Yadong vs Kyler Phillips (men’s bantamweight bout)
Joseph Benavidez vs Askar Askarov (men’s flyweight bout)
Rogerio Bontorin vs Kai Kara-France (men’s flyweight bout)
Tim Elliott vs Jordan Espinosa (men’s flyweight bout)
Kennedy Nzechukwu vs Carlos Ulberg (men’s light-heavyweight bout)
Sean Brady vs Jake Matthews (men’s welterweight bout)
Livinha Souza vs Amanda Lemos (women’s strawweight bout)
Uros Medic vs Aalon Cruz (men’s lightweight bout)
Mario Bautista vs Trevin Jones (men’s bantamweight bout)
UFC 259 predictions
Adesanya to win via unanimous decision
Nunes to win via KO/TKO
Sterling to win via submission
We’re backing the dominant Adesanya to become only the fifth UFC fighter ever to hold two world title belts concurrently, while another stoppage for Nunes seems the safe bet and Sterling is well capable of dethroning Yan with his superior ground game.
UFC 259 betting odds and tips
Adesanya to win: 1/2
Blachowicz to win: 2/1
Nunes to win: 1/8
Anderson to win: 7/1
Yan to win: 10/11
Sterling to win: 21/20
Odds via Betfair Exchange (subject to change). Click here to find out more.