Arsenal manager Mikel Arteta has named Bukayo Saka on the bench as the Gunners welcome Leeds to the Emirates Stadium, but Gabriel Jesus makes his first Premier League start since the World Cup.
It is the first time Saka has not started a League game this season, while William Saliba is out due to a back injury picked up in the Europa League earlier this month.
Rob Holding, who has started just one top-flight game this season, against Crystal Palace before the international break, continues in the Frenchman’s absence.
“Rob has huge experience already at the club, in the Premier League, and I think he proved that in the right way in the last game against Palace,” said Arteta on Friday.
Thomas Partey is fit for Arsenal after missing Ghana’s draw with Angola on Monday, while Jesus is back in the starting lineup after working at the training ground during the international break.
“He is very close to that (100 per cent). In the last 10 days he has really made a big step forward,” Arteta said of Jesus.
“You can see that he is looser, he is not thinking about it. You can see that he is already creating in training that chaos that he is capable of creating in unique moments. He is in a really good place now.”
Eddie Nketiah is still out for Arsenal however, along with longer-term absentees Takehiro Tomiyasu and Mohamed Elneny.
Arsenal XI: Ramsdale, White, Holding, Gabriel, Zinchenko, Partey, Xhaka, Odegaard, Trossard, Jesus, Martinelli.
Subs: Tierney, Saka, Smith Rowe, Kiwior, Jorginho, Vieira, Nelson, Turner, Walters.
Saturday 3.00pm BST
Venue: Emirates Stadium
Referee: Darren England