The Japanese international was forced off during the first half of the Gunners’ damaging 2-0 defeat to Newcastle on Monday night with a muscular injury, the latest in a line of problems that have dogged the second half of an impressive first Premier League campaign.
Cedric Soares will fill in at right-back while Rob Holding starts again after suspension and could return at centre-back.
Both Ben White and Gabriel started at St. James’ Park despite injury concerns, with Arteta struggling for alternative options, and
Meanwhile, Sunday’s game could offer a farewell for the likes of Eddie Nketiah, Alexandre Lacazette and Mohamed Elneny.
All three are out of contract at the end of the season, though none of their departures have yet been confirmed and Elneny in particular is reportedly being lined up for a new contract.
He starts alongside Nketiah, with Lacazette on the bench.
Arsenal starting lineup: (4-3-3)Ramsdale, Cedric, Holding, Gabriel, Tavares, Elneny, Xhaka, Odegaard, Saka, Nketiah, Martinelli
When: Sunday, May 22, 4pm BST
Venue: Emirates Stadium
Referee: Andre Marriner
Arsenal squad from: Leno, Ramsdale, Okonkwo; Cedric, Gabriel, Holding, Tavares, White; Elneny, Lokonga, Odegaard, Patino, Saka, Smith Rowe, Xhaka; Lacazette, Martinelli, Nketiah, Pepe.
Doubt: Tomiyasu (thigh)
Injured: Partey (thigh), Tierney (knee)