The Gunners were left devastated after a goalless draw at home to Villarreal meant Mikel Arteta’s side crashed out of the Europa League.
It leaves Arsenal looking at the likely prospect of no European football next season.
Meanwhile, West Brom will be relegated if they lose.
Here’s everything you need to know about the match.
When is it?
The fixture will kick-off at 7pm BST at the Emirates Stadium.
How can I watch it?
The match is live on Sky Sports Premier League and Main Event with coverage starting from 6:30pm. Subscribers can stream the match via the Sky Go app.
If you’re not a Sky customer you can grab a NOWTV Day Pass here to watch without a subscription.
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What is the team news?
Granit Xhaka is in contention to play after missing the draw with Villarreal, while Dani Ceballos is available. David Luiz is unlikely to feature as he recovers from a hamstring issue.
Ainsley Maitland-Niles is ineligible to face his parent club, while Branislav Ivanovic, Robert Snodgrass and Kieran Gibbs are out.
Arsenal: Leno; Chambers, Holding, Gabriel, Saka; Ceballos, Elneny; Pepe, Smith Rowe, Willian; Martinelli.
West Brom: Johnstone; Furlong, Ajayi, Bartley, Townsend; Phillips, Yokuslu, Gallagher, Robinson; Matheus Pereira; Diagne.
West Brom: 6/1
The Gunners will be deflated after their Europa League exit, but anything less than a win will raise the already intense pressure on Mikel Arteta. The Gunners will get a win here. 2-1 to Arsenal.