Iwobi was dismissed after his yellow card for a challenge on Youssef Msakni was upgraded to red after a VAR check in the 64th minute.
The three-time AFCON winners were already trailing to Msakni’s strike from distance two minutes after the restart, with the ball squirming through Maduka Okoye’s grasp.
There was no way back for them with Tunisia advancing to a quarter-final date with Burkina Faso.
FULL-TIME! ⏰ #TeamNigeria 0️⃣-1️⃣ #TeamTunisia
The Eagles of Carthage qualify to the quarter-finals courtesy of a Youssef Msakni rocket 🚀 #TotalEnergiesAFCON2021 | #AFCON2021| #NGATUN pic.twitter.com/juWXM4PsOI
— #TotalEnergiesAFCON2021 🏆 (@CAF_Online) January 23, 2022
Nigeria’s exit means a number of British clubs will be able to welcome back some key players to domestic action.
Kemar Roofe and Joe Aribo can return to Rangers in time for the Old Firm derby with Celtic while Kelechi Iheanacho and Wilfred Ndidi will head back to aid Leicester’s push for European football.
Burkina Faso booked their last-eight spot with a 7-6 penalty shootout win over 10-man Gabon after it had ended 1-1 after 120 minutes.